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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor

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Molecular mechanics calculations on conformers ofAc-HGly-NHMe, Ac-b2-HAla-NHMe and Ac-b3-HAla-NHMe indicate that low-energy conformations of theb-amino acids backbone, corresponding to gauche rotamersaround the Ca–Cbbond, may overlap canonical backboneconformers observed for a-amino acids. Therefore, Sub-stance P (SP) was used as a model peptide to analyse thestructural and biological consequences of the substitution ofPhe7andPhe8by(R)-b2-HPheandofGly9byHGly (R)-b2-HAla or (S)-b3-HAla....
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor

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