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NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase (HGDH) cata-lyses the reduction of 2-oxoglutarate to (R)-2-hydroxyglutarate and belongsto the D-2-hydroxyacid NAD+-dependent dehydrogenase (D-2-hydroxyaciddehydrogenase) protein family. Its crystal structure was determined byphase combination to 1.98 A˚resolution. Structure–function relationshipsobtained by the comparison of HGDH with other members of theD-2-hydroxyacid dehydrogenase family give a chemically satisfying view of thesubstrate stereoselectivity and catalytic requirements for the hydride trans-fer reaction. A model for substrate recognition and turnover is discussed....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Structural basis for stereo-specific catalysis in NAD+-dependent (R )-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans
