Báo cáo khóa học: Structural characterization of the human Nogo-A functional domains Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration
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The recent discovery of theNogo family ofmyelin inhibitorsand theNogo-66 receptor opens upa very promising avenuefor the development of therapeutic agents for treating spinalcord injury. Nogo-A, the largest member of the Nogo fam-ily, is a multidomain protein containing at least two regionsresponsible for inhibiting central nervous system (CNS)regeneration. So far, no structural information is availablefor Nogo-A or any of its structural domains. We have sub-cloned and expressed two Nogo-A fragments, namely the182 residueNogo-A(567–748) and the 66 residueNogo-66 inEscherichia coli....
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Báo cáo khóa học: Structural characterization of the human Nogo-A functional domains Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration
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Báo cáo khóa học: Structural characterization of the human Nogo-A functional domains Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration
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