Báo cáo khoa học: Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics
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Enolase is a validated drug target inTrypanosoma brucei. To better charac-terize its properties and guide drug design efforts, we have determined sixnew crystal structures of the enzyme, in various ligation states and confor-mations, and have carried out complementary molecular dynamics simula-tions.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics
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