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Phosphorylation at multiple sites within the N-terminus ofp53 promotes its dissociation from hdm2/mdm2 and sti-mulates its transcriptional regulatory potential. The largephosphoinositide 3-kinase-like kinases ataxia telangiectasiamutated gene product and the ataxia telangectasia andRAD-3-related kinase promote phosphorylation of humanp53at Ser15andSer20, andare required for theactivationofp53 following DNA damage. DNA-dependent protein kin-ase (DNA-PK) is another large phosphoinositide 3-kinase-like kinase with the potential to phosphorylate p53 at Ser15,and has been proposed to enhance phosphorylation of thesesites in vivo....
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Báo cáo khoa học: Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18
