Báo cáo khoa học: Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor
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Highly active, small-molecule furin inhibitors are attractive drug candidatesto fend off bacterial exotoxins and viral infection. Based on the 22-residue,active Lys fragment of the mung bean trypsin inhibitor, a series of furininhibitors were designed and synthesized, and their inhibitory activitytowards furin and kexin was evaluated using enzyme kinetic analysis.
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Báo cáo khoa học: Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor
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Báo cáo khoa học: Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor
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