Báo cáo khoa học: The bI/bIII-tubulin isoforms and their complexes with antimitotic agents
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Both microtubule destabilizer and stabilizer agents are important moleculesin anticancer therapy. In particular, paclitaxel has been demonstrated to beeffective for the treatment of ovarian, breast, and nonsmall cell lung carci-nomas. It has been shown that emergence of resistance against this agentcorrelates with an increase in the relative abundance of tubulin isoformbIII and that the more recently discovered IDN5390 can be effectively usedonce resistance has emerged.
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Báo cáo khoa học: The bI/bIII-tubulin isoforms and their complexes with antimitotic agents
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The bI/bIII-tubulin isoforms and their complexes with antimitotic agents
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