Báo cáo khoa học: The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features
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Glucose-6-phosphate isomerase catalyzes the reversiblealdose-ketose isomerization of D-glucose-6-phosphate toD-fructose-6-phosphate in glycolysis and gluconeogenesis,and in the recycling of hexose-6-phosphate in the pentosephosphate pathway. The unicellular protozoans,Trypan-osoma brucei, T. cruziandLeishmaniaspp., of the orderKinetoplastida are important human parasites responsiblefor African sleeping sickness, Chagas’ disease and leish-maniases, respectively. In these parasites, glycolysis is animportant (and in some cases the only) metabolic pathwayfor ATP supply....
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Báo cáo khoa học: The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features
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Báo cáo khoa học: The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features
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