Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2
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The transporter associated with antigen processing (TAP)delivers peptides into the lumen of the endoplasmic reticu-lum for binding onto major histocompatibility complexclass I molecules. TAP comprises two polypeptides,TAP1andTAP2,eachwithanN-terminal transmembranedomainand a C-terminal cytosolic nucleotide binding domain(NBD). The two NBDs have distinct intrinsic nucleotidebinding properties.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2
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