Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation
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Protein aggregation can proceed via disordered or ordered mechanisms,with the latter being associated with amyloid fibril formation, which hasbeen linked to a number of debilitating conditions including Alzheimer’s,Parkinson’s and Creutzfeldt-Jakob diseases. Small heat-shock proteins(sHsps), such as aB-crystallin, act as chaperones to prevent protein aggre-gation and are thought to play a key role in the prevention of protein-mis-folding diseases.
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Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation
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