Báo cáo khoa học: The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase
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Here we examine the enantioselectivity of the allosteric and substrate bind-ing sites of murine ribonucleotide reductase (mRR). l-ADP binds to theactive site andl-ATP binds to both the s- and a-allosteric sites of mR1with affinities that are only three- to 10-fold weaker than the values for thecorresponding d-enantiomers. These results demonstrate the potential ofl-nucleotides for interacting with and modulating the activity of mRR, acancer chemotherapeutic and antiviral target.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase
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