Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines
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The cAMP response element consensus sequence directs thetranscription of a wide range of genes. A 24-mer single-stranded cAMP response element decoy oligonucleotide(CDO) has been shown to compete with these sequences forbinding transcription factors and therefore interferes withcAMP-induced gene transcription. We have examined theeffect of this CDOalone and in combinationwith a range ofcommon chemotherapeutic agents in colorectal cancer celllines.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines
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