Báo cáo khoa học: The lipid ⁄ protein interface as xenobiotic target site Kinetic analysis of tadpole narcosis
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High-resolution X-ray diffraction structures of integral membrane proteinshave revealed various binding modes of lipids, but current spectroscopicstudies still use uniform macroscopic binding constants to describe lipidbinding. The Adair approach employing microscopic lipid-binding con-stants has previously been taken to explain the enhancement of agonistbinding to the nicotinic acetylcholine receptor by general anaesthetics interms of the competitive displacement of essential lipid activator molecules[Walcher S, Altschuh J & Sandermann H (2001) J. Biol. Chem. 276,42191–42195]....
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Báo cáo khoa học: The lipid ⁄ protein interface as xenobiotic target site Kinetic analysis of tadpole narcosis
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Báo cáo khoa học: The lipid ⁄ protein interface as xenobiotic target site Kinetic analysis of tadpole narcosis
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