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Most of the examples of protein translocation across amembrane (such as the import of classical secretory proteinsinto the endoplasmic reticulum, import of proteins intomitochondria and peroxisomes, as well as protein importinto and export from the nucleus), are understood in greatdetail. In striking contrast, the phenomenon of unconven-tional protein secretion (also known as nonclassical proteinexport or ER/Golgi-independent protein secretion) fromeukaryotic cells was discoveredmore than 10 years ago andyet the molecular mechanism and the molecular identity ofmachinery components that mediate this process remainelusive. ...
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The mystery of nonclassical protein secretion A current view on cargo proteins and potential export routes
