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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases

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10.10.2023

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The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPasesSorting of membrane proteins into intralumenal endosomal vesicles, mul-tivesicular body (MVB) sorting, is critical for receptor down regulation,antigen presentation and enveloped virus budding. Vps4 is an AAAATPase that functions in MVB sorting. Although AAA ATPases are oligo-meric, mechanisms that govern Vps4 oligomerization and activity remainelusive.Parimala R. Vajjhala1,2, Chau H. Nguyen1,2, Michael J. Landsberg1, Carol Kistler1,2, Ai-Lin Gan1,2, Glenn F. King1, Ben Hankamer1 and Alan L. Munn1,2,3,41 2 3 4 Institute for Molecular Bioscience, The...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases

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