Báo cáo khoa học: Thioredoxin reductase from the malaria mosquito Anopheles gambiae Comparisons with the orthologous enzymes of Plasmodium falciparum and the human host
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Themosquito,Anopheles gambiae, is an important vector ofPlasmodium falciparum malaria. Full genome analysisrevealed that, as in Drosophila melanogaster,the enzymeglutathione reductase is absent inA. gambiaeand func-tionally substituted by the thioredoxin system. The keyenzyme of this system is thioredoxin reductase-1, a homo-dimeric FAD-containing protein of 55.3 kDa per subunit,which catalyses the reaction NADPH + H++ thio-redoxin disulfidefiNADP++ thioredoxin dithiol.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Thioredoxin reductase from the malaria mosquito Anopheles gambiae Comparisons with the orthologous enzymes of Plasmodium falciparum and the human host
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Thioredoxin reductase from the malaria mosquito Anopheles gambiae Comparisons with the orthologous enzymes of Plasmodium falciparum and the human host
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