Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model
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We have shown that the ABC transporter, multiple drug resistanceprotein 1 (MDR1, P-glycoprotein) translocates glucosyl ceramide fromthe cytosolic to the luminal Golgi surface for neutral, but not acidic, gly-cosphingolipid (GSL) synthesis. Here we show that the MDR1 inhibitor,cyclosporin A (CsA) can deplete Gaucher lymphoid cell lines of accumu-lated glucosyl ceramide and Fabry cell lines of globotriaosyl ceramide(Gb3), by preventing de novosynthesis.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model
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