Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure
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The deacetylase inhibitor trichostatin A (TSA) has longbeen used to study the relationship between gene transcrip-tion and the acetylation status of chromatin. We haveusedXenopus laevisoocytes to study the effects of TSA onglucocorticoid receptor (GR)-dependent transcription andwe have related these effects to changes in the chromatinstructure of a reporter mouse mammary tumor virus(MMTV) promoter. We show that TSA induces a low levelof constitutive transcription.
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Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure
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Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure
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Report medicine traditional medicine scientific reports medicine cell proliferation oxidationTài liệu liên quan:
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