Báo cáo nghiên cứu khoa học: Nghiên cứu về nhiễm HBV mãn tính và các yếu tố gây nhiễm ở những bệnh nhân bị ung thư gan trong bệnh viện của trường Cao đẳng Y Dược Huế

Tuyển tập báo cáo nghiên cứu khoa học trường đại học huế đề tài: Nghiên cứu về nhiễm HBV mãn tính và các yếu tố gây nhiễm ở những bệnh nhân bị ung thư gan trong bệnh viện của trường Cao đẳng Y Dược Huế...
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Báo cáo nghiên cứu khoa học: " Nghiên cứu về nhiễm HBV mãn tính và các yếu tố gây nhiễm ở những bệnh nhân bị ung thư gan trong bệnh viện của trường Cao đẳng Y Dược Huế"JOURNAL OF SCIENCE, Hue University, N0 61, 2010 RESEARCH ON CHRONIC HBV INFECTION AND RISK FACTORS IN PATIENTS WITH LIVER CANCER IN THE HOSPITAL OF HUE COLLEGE OF MEDICINE AND PHARMACY Vo Dang Anh Thu, Nguyen Thi Kim Hoa, Pham Van Linh College of Medicine and Pharmacy, Hue University SUMMARY Research on the risk factors of liver cancer, particularly HBV infection is necessary forpreventing liver cancer and to reduce the prevalence of this cancer in future. Objectives: Toidentify the risk factors among patients with liver cancer in Hue college of Medicine andPharmacy. Methods: A case-control study was conducted from May 2007 to May 2008 in whichthere were 40 patients with liver cancer and 40 people without any liver diseases. For eachpatient, there was a person in the control group has the same age, gender and living areas.Results: (1) The average age of the study subjects was 53.7±8.9 in which age 54.3±12.1 was themean for men and age 52.9±8.9 for women, 50% of liver cancer patients aged from 45 to 60.The ratio of men to women was 3 to 1. (2) The risk factors of liver cancer include: HBsAg (+)(OR = 17.0), history of alcohol consumption (OR=7.0), drinking frequency (OR=4.5), thevolume of alcohol intake (OR=5.18), tobacco consumption (OR = 2.51), familial history of livercancer (OR = 5.52). (3) The exposure to organic pesticides is not associated with liver cancer(OR=1.48, p>0.05, χ2= 0.39). Conclusion: This research was useful in identifying risk factorsof liver cancer. The results from this research will be used to inform the community and futurestudy of the risk factors of liver cancer.1. Introduction Liver cancer is one of the most common cancers worldwide. This is the fifthmost common cause of cancer in men and the eighth most common cause in women. InVietnam, liver cancer is also a common and serious cancer that affects men more oftenthan women, and which was ranked the third most common cancer in men and the sixthin women. As in many Asian countries, Vietnam is one of the countries that have a highprevalence of liver cancer due to the high proportion of hepatitis B and C infection. Major risk factors of hepatocellular carcinoma are hepatitis B and C. Thereto,alcohol and cirrhosis also largely contribute to the causes of this serious cancer. Onestudy has shown that alcoholics were two times more likely than non-alcoholics todevelop liver cancer, and twenty-two times more likely to develop liver cancer if there 459was cirrhosis induced by alcohol. Meanwhile, aflatoxin B1 is the main causal factor oflive cancer due to chemicals. Research on risk factors of liver cancer, particularly HBVinfection are necessary for preventing liver cancer and contributing to the reduction inthe prevalence of this cancer in the future. This study was conducted in order todetermine the relationship between chronic hepatitis B virus infection and other riskfactors among patients with liver cancer.2. Methodology A case-control study was done from May 2007 to May 2008. 2.1. Sample Using the formula of Schlesselman3: Z  2 2u 1  u   Zβ f 1  f   p 3q 3 α n f  p 3 2 fOR 1  p OR q 3  1  p3 u f 1  2  1  f OR  1  1  f OR  1 3  Predicted: f = 0.35; OR = 3.5; accepted:  = 0.05;  = 0.2; → n  40 2.2. Selection of cases and controls The cases were 40 patients with liver cancer who were under treatment at thehospital of Hue college of Medicine and Pharmacy. Under the principle of the sameliving area, sex and age, 40 non-liver cancer subjects were selected as controls.Consequently, the study subjects include 40 cases and 40 controls. 2.3. Contents of the study The study contents composed of three parts as follow: (1).Generalcharacteristics; (2). Personal habits: including alcohol consumption and cigarettesmoking; (3). Symptoms and disease history related with liver cancer. 2.4. Investigation methods the constructed questionnaire was used to collect data. All interviewers weretrained ...