Báo cáo sinh học: Introducing the Neurosciences Section of the Journal of Translational Medicine

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Báo cáo sinh học: " Introducing the Neurosciences Section of the Journal of Translational Medicine"Alguacil Journal of Translational Medicine 2011, 9:117http://www.translational-medicine.com/content/9/1/117 EDITORIAL Open AccessIntroducing the Neurosciences Section of theJournal of Translational MedicineLuis F Alguacil“We must seriously think about proceeding further than new ways to overcome this bottleneck seems therefore alooking for cures just for rodents”. These ironic words major challenge for neuroscientists.were recently pronounced in a public forum by a medi- When significant advances are finally achieved in basiccal doctor devoted to basic research, who decided to science, and even in the case that they look promising inmove from experimentation in rat arteries to human randomized clinical trials, prominent barriers still remainvessels in her search for new targets for cardiovascular to prevent fast translations into clinical practice. These arediseases. Scientists dealing with basic neuropsychiatric the targets of the so-called T2 translational research, as defined by the American Institute of Medicine’s Clinicalresearch must seriously e xamine this question andanother one even more critical: are we looking for cures Research Roundtable. T2 research deals with problemsfor diseases in biological systems not willing to suffer such as cost-effectiveness and feasibility of implementationthem in nature? In other words: can we consider spon- in health care systems. The need for promoting T2 researchtaneous dementia, anorexia nervosa, addiction or schizo- and its coupling with new developments from basic neu- roscience has been recently qualified as “urgent” by NIMHphrenia specific human diseases? If so... is it intelligenttrying to progress in the knowledge of these pathologies investigators working on psychotic disorders, especiallyon the basis of home-made, artificial animal models? worried about the outcome of extremely vulnerable popula-Must we persist on this way or center exclusively on tions. Besides psychiatrists, neurologists have also expressedhuman experimentation? the opportunity of encouraging all the steps of translational The bench to bedside two-way travel is always proble- research from basic science to the clinics and backwards, amatic, but it appears especially difficult when dealing process which is expected to render promising results inwith neuropsychiatric disorders where psychosocial vari- prioritized research areas (s troke, headache, multipleables seem to play an essential role, both in the emer- sclerosis, epilepsy and dementias, in the case of the US).gence and maintenance of the problem. This fact Translational research on neuropsychiatric disorders isextremely complicates laboratory modeling. It is clear less developed than in other areas (i.e. oncology), but it isthat the fast development of the neurosciences along the an emerging issue. Any new tool for the dissemination ofXX century has led to important medical progress, results in the field can greatly help to progress in theenabling therapists to use modern, advanced tools (i.e., achievement of new solutions for the neuropsychiatricrationale-based designed drugs instead of serendipity- patient, and this is the main goal of the new Neuros-based old remedies). However, a significant gap still per- ciences Section of the Journal of Translational Medicine.sists between basic science and medical applications for We hope to encourage publications and promote thethe patients, in part due to the shortage (sometimes increase of knowledge on the subject by collecting origi-absence) of preclinical models with enough face, con- nal articles together in this new ...