Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor
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Ligand binding by the aryl hydrocarbon receptor (AhR), amember of the bHLH-PAS family of transcriptional reg-ulatory proteins, has been mapped to a region within thesecond ÔPASÕ domain, a conserved sequence motif ®rstdiscovered in the Per-ARNT-Sim family of proteins. Inaddition to the bacterial photoactive yellow protein (PYP),which had been proposed as a structural prototype for thethree dimensional fold of PAS domains, two crystalstructures of the PAS domain have recently been deter-mined: the human potassium channel HERG and theheme binding domain of the bacterial O2 sensing FixLprotein. ...
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Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor
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Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor
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