Báo cáo Y học: Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate
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We have recently identified an Ets element controlling over90%of the basal expression of the human presenilin 1 (PS1)gene. We have also shown that Ets1 and Ets2 act as trans-activators of the PS1 gene by cotransfection experiments inSK-N-SH neuronal cells. The PS1 gene is widely but dif-ferentially expressed across tissues and the expression inbrain appears to be restricted to neurons. To gain furtherinsight into the regulation of the gene we have examined theregulation of PS1 by 12-O-tetradecanoylphorbol 13-acetate(TPA). ...
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Báo cáo Y học: Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate
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