Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes
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Human cytochrome P450 17a-hydroxylase (CYP17) cata-lyses not only the 17a-hydroxlation of pregnenolone andprogesterone and the C17,20-side chain cleavage (lyase) of17a-hydroxypregnenolone, necessary for the biosynthesis ofC21-glucocorticoids and C19-androgens, but also catalysesthe 16a-hydroxylation of progesterone. In efforts to under-stand the complex enzymology of CYP17, structure/func-tion relationships have been reported previously afterexpressingrecombinant DNAs, encodingCYP17 fromvarious species, in nonsteroidogenic mammalian or yeastcells. ...
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Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes
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