Báo cáo y học: Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study...
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Báo cáo y học: "Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study" Available online http://ccforum.com/content/11/5/R96Research Open AccessVol 11 No 5Clinical risk conditions for acute lung injury in the intensive careunit and hospital ward: a prospective observational studyNiall D Ferguson1, Fernando Frutos-Vivar2, Andrés Esteban2, Federico Gordo3, Teresa Honrubia4,Oscar Peñuelas2, Alejandro Algora3, Gema García4, Alejandra Bustos2 and Inmaculada Rodríguez21Interdepartmental Division of Critical Care Medicine, and Department of Medicine, Division of Respirology, University Health Network, University ofToronto, 399 Bathurst Street, F2-150, Toronto, Ontario M5T 2S8, Canada2Intensive Care Unit, Hospital Universitario de Getafe, CIBER de Enfermades Respiratorios, Carretera de Toledo Km 12,500, 28905 Madrid, Spain3Intensive Care Unit, Fundacíon Hospital de Alcorcón, c/Budapest 1, 28922 Alcorcón, Madrid, Spain4Intensive Care Unit, Hospital de Móstoles, c/Río Jucar, 28935 Móstoles, Madrid, SpainCorresponding author: Niall D Ferguson, n.ferguson@utoronto.caReceived: 21 Dec 2006 Revisions requested: 14 Feb 2007 Revisions received: 23 Aug 2007 Accepted: 4 Sep 2007 Published: 4 Sep 2007Critical Care 2007, 11:R96 (doi:10.1186/cc6113)This article is online at: http://ccforum.com/content/11/5/R96© 2007 Ferguson et al.; licensee BioMed Central Ltd.This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.AbstractBackground Little is known about the development of acute sepsis (46/53; 86.7%), but shock (21/59; 36%) andlung injury outside the intensive care unit. We set out to pneumonia (20/211; 9.5%) portended the highest proportionaldocument the following: the association between predefined risk; this risk was higher in patients with increasing numbers ofclinical conditions and the development of acute lung injury by clinical risk conditions (2.2%, 14%, and 21% (P < 0.001) inusing the American–European consensus definition; the patients with one, two, and three conditions, respectively).frequency of lung injury development outside the intensive care Median days (interquartile range) from risk condition tounit; and the temporal relationship between antecedent clinical diagnosis of lung injury was shorter with pulmonary (0 (0 to 2))risk conditions, intensive care admission, and diagnosis of lung versus extrapulmonary (3 (1 to 5)) (P = 0.029) risk conditions.injury. Admission to the intensive care unit was provided to 9/20 (45%) patients with acute lung injury and to 29/33 (88%) of those withMethods We conducted a 4-month prospective observational acute respiratory distress syndrome. Lung injury patients hadstudy in three Spanish teaching hospitals, enrolling consecutive higher mortality than others (acute lung injury 25.0%; acutepatients who developed clinical conditions previously linked to respiratory distress syndrome 45.5%; others 10.3%; P