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Báo cáo Y học: Complexation of ytterbium to human transferrin and its uptake by K562 cells

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There is an increasing interest in the use of lanthanides inmedicine. However, themechanismof their accumulation incells isnotwell understood.Lanthanidecations are similar toferric ions with regard to transferrin binding, suggestingtransferrin-receptormediated transport is possible; however,this has not yet been confirmed. In order to clarify thismechanism, we investigated the binding of Yb3+to apo-transferrin by UV-Vis spectroscopy and stopped-flow spec-trophotometry, and found that Yb3+binds toapotransferrin at the specific iron sites in the presence ofbicarbonate. ...
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Báo cáo Y học: Complexation of ytterbium to human transferrin and its uptake by K562 cells

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