Báo cáo y học: Immunohistochemical identification of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal carcinoma: a case report.

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Báo cáo y học: " Immunohistochemical identification of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal carcinoma: a case report."Journal of Medical Case Reports BioMed Central Open AccessCase reportImmunohistochemical identification of primary peritoneal serouscystadenocarcinoma mimicking advanced colorectal carcinoma: acase reportWesley B von Riedenauer*1, Sumbul A Janjua1,3, David S Kwon1,Ziying Zhang2 and Vic Velanovich1Address: 1Department of Surgery, Henry Ford Hospital, Detroit, Michigan, USA, 2Department of Pathology, Henry Ford Hospital, Detroit,Michigan, USA and 3The Aga Khan University Medical College, Karachi, PakistanEmail: Wesley B von Riedenauer* - vonriedenauer@yahoo.com; Sumbul A Janjua - sumbuljanjua@hotmail.com;David S Kwon - dkwon1@hfhs.org; Ziying Zhang - ZZHANG2@hfhs.org; Vic Velanovich - VVELANO1@hfhs.org* Corresponding authorPublished: 26 November 2007 Received: 24 June 2007 Accepted: 26 November 2007Journal of Medical Case Reports 2007, 1:150 doi:10.1186/1752-1947-1-150This article is available from: http://www.jmedicalcasereports.com/content/1/1/150© 2007 von Riedenauer et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Primary peritoneal cystadenocarcinoma is a rare tumor of similar histogenic origin as primary ovarian carcinoma. We present a case of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal cancer in a 68 yr-old African American female. Radiology, endoscopy and cytology yielded only inconclusive findings. Immunohistochemical analysis of percutaneously obtained ascitic fluid provided a correct diagnosis of primary peritoneal cystadenocarcinoma. The discovery of serous ascites at the time of laparotomy confirmed a diagnosis of primary peritoneal serous cystadenocarcinoma. Final surgical pathology reconfirmed the diagnosis of primary peritoneal cystadenocarcinoma. This case demonstrates the utility of immunohistochemistry for accurately diagnosing patients with inconclusive findings in the setting of peritoneal carcinomatosis and primary peritoneal cystadenocarcinoma. ian carcinoma may present as a solitary mass, but is theIntroductionPrimary peritoneal cystadenocarcinoma is a rare tumor most common cause of carcinomatosis in women. Pri-[1]. Originally described by Swerdlow in 1959, the true mary peritoneal cystadenocarcinoma uniformly presentsincidence of primary peritoneal cystadenocarcinoma as disseminated intraperitoneal carcinomatosis.remains unknown although an estimated relative fre-quency to ovarian cancer is 1:10[2]. Better recognition of Both primary ovarian carcinoma and primary peritonealthis entity in recent years has contributed to an increasing cystadenocarcinoma can present with carcinomatosis.diagnostic frequency approaching 18% of laparotomies Clinical presentation results from local tumor effectsperformed for ovarian carcinoma [2]. Synonyms for pri- involving multiple organs [3]. Common symptomsmary peritoneal cystadenocarcinoma include primary include abdominal distension/ascites, dyspnea, nausea,peritoneal papillary carcinoma, extraovarian peritoneal vomiting and constipation. The most common presentingpapillary carcinoma, peritoneal mesothelioma, surface complaints are ascites, abdominal mass and pleural effu-papillary carcinoma, primary peritoneal carcinoma, and sion. Both primary ovarian carcinoma and primary perito-multiple focal extraovarian carcinoma [1]. Primary ovar- neal cystadenocarcinoma have serous and mucinous Page 1 of 5 ...