Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells
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The C-terminus of thea-chain of tubulin is subject toreversible incorporationof tyrosineby tubulin tyrosine ligaseand removal by tubulin carboxypeptidase. Thus, microtu-bules rich in either tyrosinated or detyrosinated tubulin cancoexist in the cell. Substitution of the terminal tyrosine by3-nitrotyrosine has been claimed to cause microtubule dys-function and consequent injury of epithelial lung carcinomaA549 cells. Nitrotyrosine is formed in cells by nitration oftyrosine by nitric oxide-derived species....
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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells
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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells
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