Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules
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The efficacy of antiretroviral agents approved for the treat-ment of HIV-1 infection is limited by the virus’s ability todevelop resistance. As such there is an urgent need for newways of thinking about anti-HIV drug development, andaccordingly novel viral and cellular targets critical toHIV-1replication need to be explored and exploited. The retroviralRNA genome encodes for three enzymes essential for viralreplication: HIV-1 protease (PR), HIV-1 reverse transcrip-tase (RT) and HIV-1 integrase (IN). ...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules
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