Báo cáo y học: Multiple organ failure after trauma affects even long-term survival and functional status

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Multiple organ failure after trauma affects even long-term survival and functional status...
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Báo cáo y học: " Multiple organ failure after trauma affects even long-term survival and functional status" Available online http://ccforum.com/content/11/5/R95Research Open AccessVol 11 No 5Multiple organ failure after trauma affects even long-term survivaland functional statusAtle Ulvik1,2, Reidar Kvåle1, Tore Wentzel-Larsen3 and Hans Flaatten1,21Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway2Section for Anaesthesiology and Intensive Care, Department of Surgical Sciences, University of Bergen, Bergen, Norway3Centre for Clinical Research, Haukeland University Hospital, Bergen, NorwayCorresponding author: Atle Ulvik, atle.ulvik@helse-bergen.noReceived: 3 May 2007 Revisions requested: 9 Jul 2007 Revisions received: 10 Aug 2007 Accepted: 4 Sep 2007 Published: 4 Sep 2007Critical Care 2007, 11:R95 (doi:10.1186/cc6111)This article is online at: http://ccforum.com/content/11/5/R95© 2007 Ulvik et al.; licensee BioMed Central Ltd.This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.AbstractBackground The aim of this study was to assess the incidence regression, MOF increased the overall risk of death 6.0 times. Atof organ failure in trauma patients treated in an intensive care follow-up, 242 patients (75%) were still alive. Patients with MOFunit (ICU), and to study the relationship between organ failure had 3.9 times greater odds for requiring personal assistance inand long-term survival and functional status. activities of daily living compared to patients without organ failure. Long-term survival and functional status were the sameMethods This is a cohort study of all adult ICU trauma patients for patients suffering single organ failure and no organ failure.admitted to a university hospital during 1998 to 2003. Organ Complete recovery occurred in 52% of survivors, and 87% werefailure was quantified by the Sequential Organ Failure able to look after themselves.Assessment (SOFA) score. A telephone interview wasconducted in 2005 (2 to 7 years after trauma) using the Conclusion Almost half of the ICU trauma patients had MOF.Karnofsky Index to measure functional status, and the Glasgow While single organ failure had no impact on long-termOutcome Score to measure recovery. outcomes, the presence of MOF greatly increased mortality and the risk of impaired functional status. MOF expressed by SOFAResults Of the 322 patients included, 47% had multiple organ score may be used to define trauma patients at particular risk forfailure (MOF), and 28% had single organ failure. In a Cox poor long-term outcomes. outcome, such as ICU mortality [1], but the relationship to long-term outcomes is more obscure.IntroductionMultiple organ failure (MOF) is the leading cause of morbidity The aim of the present study was to assess the incidence andand mortality in critically ill patients [1]. Recent studies report severity of organ failure in trauma patients admitted to the ICUan incidence of MOF of between 5% and 25% for trauma using the SOFA score. A further objective has been to studypatients admitted to the intensive care unit (ICU) [2-4]. the relationship between organ failure and mortality and func- tional status 2 to 7 years after discharge from the ICU.MOF has been defined as progressive dysfunction of two ormore organ systems following an acute threat to systemic Materials and methodshomeostasis [5]. Several organ dysfunction scoring systems Setting and study populationhave been developed to describe and quantify organ dysfunc- The study was performed in a mixed, 10-bed, closed ICU in ation/failure in ICU patients [6-8]. The Sequential Organ Failure university hospital and included neurosurgical patients. F ...