Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)
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The calcium-sensing receptor (CaR) belongs to family C ofthe G-protein coupled receptor superfamily. The receptor isbelieved to exist as a homodimer due to covalent and non-covalent interactions between the two amino terminaldomains (ATDs). It is well established that agonist bindingto family C receptors takes place at the ATD and that thiscauses theATDdimer to twist.However, very little isknownabout the translationof theATDdimer twist intoG-proteincoupling to the 7 transmembrane moieties (7TMs) of thesereceptor dimers....
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Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)
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Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)
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