Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line
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We previously demonstrated inmast cell lines RBL2H3 andFMA3 that tryptophan hydroxylase (TPH) undergoes veryfast turnover driven by 26S-proteasomes [Kojima, M.,Oguro, K., Sawabe, K., Iida, Y., Ikeda, R., Yamashita, A.,Nakanishi, N. & Hasegawa, H. (2000)J.Biochem (Tokyo)2000,127, 121–127]. In the present study, we have examinedan involvement of TPH phosphorylation in the rapid turn-over, using non-neural TPH.
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Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line
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Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line
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