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Protein synthesis requires both amino acids, as precursors,and a substantial amount of metabolic energy. It is wellestablished that starvation or lack of nutrients impairs pro-tein synthesis in mammalian cells and tissues. Branchedchain amino acids are particularly effective in promotingprotein synthesis. Recent work has revealed important newinformation about the mechanisms involved in these effects.Anumber of components of the translational machinery areregulated through signalling events that require the mam-malian target of rapamycin, mTOR. ...
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Báo cáo Y học: Regulation of mammalian translation factors by nutrients
