Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression
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Antisense oligodeoxynucleotides (AS-ODNs) are frequentlyused for the down-regulation of protein expression.Becausethe majority of potential antisense sequences lacks effect-iveness, fast screening methods for the selection of effectiveAS-ODNs are needed.We describe a new cellular screeningassay for the evaluationof the potency and specificityof newantisense sequences.
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression
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