Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain
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The major components of neuritic plaques found inAlzheimer disease (AD) are peptides known as amyloidb-peptides (Ab),which derive from the proteolitic cleavageof theamyloidprecursorproteins.InvitroAbmayundergoaconformational transition from a soluble form to aggrega-ted,fibrillary b-sheet structures,which seem to be neuro-toxic. Alternatively,it has been suggested that ana-helicalform can be involved in a process of membrane poration,which would then trigger cellular death.
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain
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