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Triacylglycerols secreted by liver and carried by very lowdensity lipoprotein (VLDL) are hydrolysed in circulation bylipoprotein and hepatic lipases. These enzymes have beenshown to have positional and fatty acid specificityin vitro.Ifthere were specificity in basal lipolysisin vivo, triacylglycerolcompositionsofcirculatingandnewlysecretedVLDLwouldbe different. To study this we compared the composition ofnormal fasting VLDL triacylglycerol of Wistar rats to thatobtained after blocking lipolysis by Triton WR1339, whichincreasedplasmaVLDL triacylglycerol concentrationabout4.7-fold in 2 h. ...
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Structural and compositional changes in very low density lipoprotein triacylglycerols during basal lipolysis
