Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex
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Tripeptidyl-peptidase II (TPP II) is a large (Mr106)tripeptide-releasing enzyme with an active site of the subtil-isin-type. Compared with other subtilases, TPP II has a 200amino-acid insertion between the catalytic Asp44 andHis264 residues, and is active as anoligomeric complex. Thisstudy demonstrates that the insert is important for theformation of the active high-molecular mass complex.
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Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex
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