Chapter 061. Disorders of Granulocytes and Monocytes (Part 7)

Miscellaneous Metabolic disorders—ketoacidosis, acute renal failure, eclampsia, acute poisoningDrugs—lithiumOther—metastatic carcinoma, acute hemorrhage or hemolysisAbnormal Neutrophil FunctionInherited and acquired abnormalities of phagocyte function are listed in Table 61-3. The resulting diseases are best considered in terms of the functional defects of adherence, chemotaxis, and microbicidal activity. The distinguishingfeatures of the important inherited disorders of phagocyte function are shown in Table 61-4.Table 61-3 Types of Granulocyte and Monocyte DisordersCause of Indicated DysfunctionFunctionDrug-InducedAcquiredInheritedAdherenceaggregationAspirin, colchicine, alcohol, state,NeonatalLeukocyte adhesion deficiency types 1 and 2glucocorticoids, ibuprofen, piroxicamhemodialysisDeformability ...
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Chapter 061. Disorders of Granulocytes and Monocytes (Part 7) Chapter 061. Disorders of Granulocytes and Monocytes (Part 7) Miscellaneous Metabolic disorders—ketoacidosis, acute renal failure, eclampsia, acutepoisoning Drugs—lithium Other—metastatic carcinoma, acute hemorrhage or hemolysis Abnormal Neutrophil Function Inherited and acquired abnormalities of phagocyte function are listed inTable 61-3. The resulting diseases are best considered in terms of the functionaldefects of adherence, chemotaxis, and microbicidal activity. The distinguishingfeatures of the important inherited disorders of phagocyte function are shown inTable 61-4. Table 61-3 Types of Granulocyte and Monocyte Disorders Cause of Indicated Dysfunction Function Drug-Induced Acquired Inherited Adherence- Aspirin, Neonatal Leukocyteaggregation colchicine, alcohol, state, adhesion glucocorticoids, hemodialysis deficiency types 1 ibuprofen, piroxicam and 2 Deformability Leukemia, neonatal state, diabetes mellitus, immature neutrophils Chemokinesis- Glucocorticoids Thermal Chédiak- (high dose), auranofin, injury, Higashi syndrome,chemotaxis colchicine (weak malignancy, neutrophil-specific effect), malnutrition, granule deficiency, phenylbutazone, periodontal hyper IgE– naproxen, disease, neonatal recurrent infection indomethacin, state, systemic (Jobs) syndrome interleukin 2 lupus (in some patients), erythematosus, Down syndrome, rheumatoid α-mannosidase arthritis, diabetes deficiency, severe mellitus, sepsis, combined influenza virus immunodeficiency, infection, herpes Wiskott-Aldrich simplex virus syndrome infection, acrodermatitis enteropathica, AIDS Microbicidal Colchicine, Leukemia, Chédiak-activity cyclophosphamide, aplastic anemia, Higashi syndrome, glucocorticoids (high certain neutrophil-specific dose), TNF-α blocking neutropenias, granule deficiency, antibodies tuftsin chronic deficiency, granulomatous thermal injury, disease, defects in sepsis, neonatal IFN-γ/IL-12 axis state, diabetes mellitus, malnutrition, AIDS Table 61-4 Inherited Disorders of Phagocyte Function: DifferentialFeatures Clinical Cellular or DiagnosisManifestations Molecular Defects Chronic Granulomatous Diseases (70% X-linked, 30% AutosomalRecessive) Severe infections of No respiratory NBT or DHR test;skin, ears, lungs, liver, and burst due to the lack of no superoxide and H2O2bone with catalase-positive one of four NADPH production bymicroorganisms such as S. oxidase subunits in neutrophils; immunoblotaureus, Burkholderia cepacia neutrophils, monocytes, for NADPH oxidase, Aspergillus spp., and eosinophils components; geneticChromobacterium violaceum ...