Chapter 097. Paraneoplastic Neurologic Syndromes (Part 5)

Specific Paraneoplastic Neurologic Syndromes(Table 97-3)Table 97-3 Antibody-Associated Paraneoplastic and Nonparaneoplastic SyndromesaAntibodiesParaneoplasticSyndromeFrequent tInfrequen sticNonparaneoplaLimbic encephalitisMa2, Hu, CV2/CRMP5, anti-NR1/NR2 of NMDA receptorTr, VGKCVGKCCerebellar degenerationYo,Tr,mGluR1;Gliadin, GADP/Q VGCC, Hu, MAZ Zic, CV2/CRMP5, Ma1-2 Ri,Hypothalamic, brainstem encephalitisMa2, Hu P5CV2/CRMEncephalomye litisHu, Zic P5,CV2/CRM Ri,amphiphysinChorea P5CV2/CRMOpsoclonusmyoclonusRi Yo,Hu, Ma2,Stiff-person syndrome sinAmphiphy RiGephyrin,GADPNH (neuromyotonia)VGKCVGKCMyastheniaAChRAChR, MuSKgravisLEMS VGCCP/Q-typeMysBP/Q-type VGCCSensory neuronopathyHuAxonal sensorimotor neuropathy ...
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Chapter 097. Paraneoplastic Neurologic Syndromes (Part 5) Chapter 097. Paraneoplastic Neurologic Syndromes (Part 5) Specific Paraneoplastic Neurologic Syndromes (Table 97-3) Table 97-3 Antibody-Associated Paraneoplastic and NonparaneoplasticSyndromesa Antibodies Paraneoplastic Syndrome Frequent Infrequen Nonparaneopla t stic Limbic Ma2, Hu, Tr, VGKC VGKCencephalitis CV2/CRMP5, anti-NR1/NR2 of NMDA receptor Cerebellar Yo, Tr, mGluR1; Gliadin, GADdegeneration P/Q VGCC, Hu, MAZ Zic, Ri, CV2/CRMP5, Ma1-2 Hypothalamic, Ma2, Hu CV2/CRMbrainstem P5encephalitis Encephalomye Hu, Zic CV2/CRMlitis P5, Ri, amphiphysin Chorea CV2/CRM P5 Opsoclonus- Ri Hu, Ma2,myoclonus Yo, Stiff-person Amphiphy Gephyrin, GADsyndrome sin Ri PNH VGKC VGKC(neuromyotonia) Myasthenia AChR AChR, MuSKgravis LEMS P/Q-type MysB P/Q-type VGCC VGCC Sensory Huneuronopathy Axonal Hu, Monoclonalsensorimotor CV2/CRMP5 gammopathy (Mneuropathy protein)b Autonomic Hu CV2/CRM Ganglionicneuropathy P5, ganglionic AChR AChR Predominant MAG, MAG,sensory ganglioside ganglioside antibodies,demyelinating antibodies: often often present withneuropathy present with MGUS Waldenströms macroglobulinem ia Paraneoplastic Recoverin Tubby-like Anti-enolaseretinopathy (CAR), anti- protein 1, PNR bipolar cell antibodies (MAR), anti- enolase a Antibodies have been validated by more than one laboratory and/or theprotein sequence of the target antigen is known. b The M protein usually does not have specific antibody activity. Note: Italics indicate that commercial testing for these antibodies is notavailable. PNH, peripheral nerve hyperexcitability; CAR, cancer-associatedretinopathy; MAR, melanoma-associated retinopathy; PNR, photoreceptor-specific nuclear receptor; MGUS, monoclonal gammopathy of uncertainsignificance; VGKC, voltage-gated potassium channel; GAD, glutamic aciddecarboxylase; AChR, acetylcholine receptor; LEMS, Lambert-Eaton myasthenicsyndrome; VGCC, voltage-gated calcium channel; MAG, myelin-associatedglycoprotein; NMDA, N-methyl-D-aspartate.