Chapter 105. Malignancies of Lymphoid Cells (Part 12)

Table 105-10 Clinical Characteristics of Patients with Common Types of Non-Hodgkins Lymphomas (NHL)Dis ease edian Age, yearsMFre quency in tageSB oneBGastro intestinal SurviChildren Male I/II vs Sympt Marro Tract III/IV, oms, % % wInvolvement, ving 5 yearsInvolve % ment, %B6Rar9373cell chronic lymphocyt ic leukemia/ small lymphocyt ic lymphoma5e3vs 91 321Ma ntle cell 36 eRar 42 0 vs 80 82 469 7lymphomaExt ranodal marginal zone cell lymphoma of MALT B 06 eRar 86 7 vs 33 91 4150 4typeFol licular lymphoma 95 eRar 23 3 vs 67 82 244 2Dif fuse large 4 B cell6 %~25 of 55 4 vs...
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Chapter 105. Malignancies of Lymphoid Cells (Part 12) Chapter 105. Malignancies of Lymphoid Cells (Part 12) Table 105-10 Clinical Characteristics of Patients with Common Typesof Non-Hodgkins Lymphomas (NHL) Dis M Fre S B B Gastroease edian quency in tage one intestinal Age, Children Male I/II vs Sympt Marro Tract Survi years III/IV, oms, w Involvement, ving % % Involve % 5 ment, years % B 6 Rar 9 3 7 3cell 5 e 3 vs 91 3 2 1chroniclymphocyticleukemia/smalllymphocyticlymphoma Ma 6 Rar 2 2 6 9ntle cell 3 e 4 0 vs 80 8 4 7lymphoma Ext 6 Rar 6 1 1 50ranodal 0 e 8 7 vs 33 9 4 4marginalzone Bcelllymphomaof MALTtype Fol 5 Rar 3 2 4 4licular 9 e 2 3 vs 67 8 2 2lymphoma Dif 6 ~25 5 3 1 18fuse large 4 % of 5 4 vs 46 3 6 6B cell childhoodlymphoma NHL Bur 3 ~30 6 2 3 11kitts 1 % of 9 2 vs 38 2 3 5lymphoma childhood NHL Pre 2 ~40 1 2 5 4cursor T8 % of 4 1 vs 89 1 0 6cell childhoodlymphobla NHLsticlymphoma An 3 Co 5 5 1 9aplastic 4 mmon 9 1 vs 49 3 3 7largeT/null celllymphoma Per 6 ~5 2 5 3 15ipheral T 1 % of 5 0 vs 80 0 6 5cell non- childhoodHodgkins NHLlymphoma Note: MALT, mucosa-associated lymphoid tissue. The diagnosis of typical B cell CLL is made when an increased number ofcirculating lymphocytes (i.e., >4 x 109/L and usually >10 x 109/L) is found (Fig.105-6) that are monoclonal B cells expressing the CD5 antigen. Finding bonemarrow infiltration by the same cells confirms the diagnosis. The peripheral bloodsmear in such patients typically shows many smudge or basket cells, nuclearremnants of cells damaged by the physical shear stress of making the blood smear.If cytogenetic studies are performed, trisomy 12 is found in 25–30% of patients.Abnormalities in chromosome 13 are also seen.