Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2)

Table 114-1 Examples of Microbial Ligand-Receptor InteractionsMicroorganismType of Microbial LigandHost ReceptorViral PathogensInfluenza virusHemagglutininSialic acidMeasles virusVaccine strainHemagglutininCD46/moesinWild-type strainsHemagglutininSignaling lymphocytic activation molecule (SLAM)Human herpesvirus type 6?CD46Herpes simplex virusGlycoprotein CHeparan sulfateHIVSurface glycoproteinCD4 and chemokine receptors CXCR4) (CCR5 andEpstein-Barr virusEnvelope proteinCD21 (=CR2)AdenovirusFiber proteinCoxsackie-adenovirus receptor (CAR)CoxsackievirusViral coat proteinsCARandmajor class IhistocompatibilityantigensBacterial PathogensNeisseria spp.PiliMembrane protein (CD46)cofactorPseudomonas aeruginosaPili and flagellaAsialo-GM1LipopolysaccharideCysticfibrosistransmembrane conductance regulator (CFTR) ...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2) Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2)Table 114-1 Examples of Microbial Ligand-Receptor InteractionsMicroorganism Type of Microbial Host Receptor LigandViral PathogensInfluenza virus Hemagglutinin Sialic acidMeasles virusVaccine strain Hemagglutinin CD46/moesin Wild-type Hemagglutinin Signaling lymphocyticstrains activation molecule (SLAM) Human ? CD46herpesvirus type 6 Herpes simplex Glycoprotein C Heparan sulfatevirus HIV Surface glycoprotein CD4 and chemokine receptors (CCR5 and CXCR4) Epstein-Barr Envelope protein CD21 (=CR2)virus Adenovirus Fiber protein Coxsackie-adenovirus receptor (CAR) Coxsackievirus Viral coat proteins CAR and major histocompatibility class I antigens BacterialPathogens Neisseria spp. Pili Membrane cofactor protein (CD46) Pseudomonas Pili and flagella Asialo-GM1aeruginosa Lipopolysaccharide Cystic fibrosis transmembrane conductance regulator (CFTR) Escherichia coli Pili Ceramides/mannose and digalactosyl residues Streptococcus Hyaluronic acid CD44pyogenes capsule Yersinia spp. Invasin/accessory β1 Integrins invasin locus Bordetella Filamentous CR3pertussis hemagglutinin Legionella Adsorbed C3bi CR3pneumophila Mycobacterium Adsorbed C3bi CR3; DC-SIGNatuberculosis FungalPathogens Blastomyces WI-1 Possibly matrixdermatitidis proteins and integrins Candida Int1p Extracellular matrixalbicans proteins ProtozoalPathogens Plasmodium Merozoite form Duffy Fy antigenvivax Plasmodium Erythrocyte-binding Glycophorin Afalciparum protein 175 (EBA-175) Entamoeba Surface lectin N-Acetylglucosaminehistolytica a A novel dendritic cell–specific C-type lectin.