Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients
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Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs.
Tìm kiếm theo từ khóa liên quan:
BMC Cancer Bilateral breast cancer Ovarian cancer ADP-ribose BRCA1/2 germline deleterious variants Clinicopathological characteristicsGợi ý tài liệu liên quan:
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