CSP I-plus modified rEndostatin inhibits hepatocellular carcinoma metastasis via down-regulation of VEGFA and integrinβ1
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In our previous study, N end of the Circumsporozoite protein (CSP I-plus) modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed, which had antiangiogenic capability and bound to hepatocellular carcinoma in vivo and in vitro. In this study, the inhibition of rES-CSP on hepatocellular carcinoma metastasis was verified in vivo and in vitro, and its possible mechanism was explored.
Tìm kiếm theo từ khóa liên quan:
BMC Cancer Hepatocellular carcinoma Tumor metastasis Liver-targeting peptide CSP I-plus Possible mechanismGợi ý tài liệu liên quan:
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