Effects of urinary extracellular vesicles from prostate cancer patients on the transcriptomes of cancer-associated and normal fibroblasts
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Increasing evidence suggests that cancer-derived extracellular vesicles (EVs) alter the phenotype and functions of fibroblasts and trigger the reprogramming of normal fibroblasts into cancer-associated fibroblasts (CAFs). Here, we for the first time studied the effects of urinary EVs from PC patients and healthy males on the transcriptional landscape of prostate CAFs and normal foreskin fibroblasts.
Tìm kiếm theo từ khóa liên quan:
BMC Cancer Extracellular vesicles Prostate cancer RNA sequencing Cancer-associated fibroblasts Transcriptional landscapeTài liệu liên quan:
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