Fatigue in breast cancer patients on chemotherapy: A cross-sectional study exploring clinical, biological, and genetic factors

Cancer-related fatigue (CRF) is one of the most common and distressing complaints reported by cancer patients during chemotherapy considerably impacting all aspects of a patient’s life (physical, psychosocial, professional, and socioeconomic).
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Fatigue in breast cancer patients on chemotherapy: A cross-sectional study exploring clinical, biological, and genetic factorsHajjetal. BMC Cancer (2022) 22:16https://doi.org/10.1186/s12885-021-09072-0 RESEARCH Open AccessFatigue inbreast cancer patientsonchemotherapy: across-sectional studyexploring clinical, biological, andgenetic factorsAlineHajj1,2*†, RamiChamoun1,2†, PascaleSalameh3,4,5, RitaKhoury1,2, RoulaHachem1,2, HalaSacre3,GeorgesChahine6, JosephKattan6and LydiaRabbaaKhabbaz1,2  Abstract  Background:  Cancer-related fatigue (CRF) is one of the most common and distressing complaints reported by cancer patients during chemotherapy considerably impacting all aspects of a patient’s life (physical, psychosocial, pro- fessional, and socioeconomic). The aim of this study was to assess the severity of cancer-related fatigue in a group of breast cancer patients undergoing chemotherapy and explore the association between fatigue scores and sociode- mographic, clinical, biological, psychiatric, and genetic factors. Methods:  A cross-sectional pilot study carried out at the oncology outpatient unit of Hôtel-Dieu de France University Hospital recruited 67 breast cancer patients undergoing chemotherapy between November 2017 and June 2019 to evaluate fatigue using the EORTC QLQ-C30 scale (European Organization for the Research and Treatment of Cancer ABCB1) was performed using the Lightcycler® (Roche). Quality of Life Questionnaire). Genotyping for seven gene polymorphisms (COMT, DRD2, OPRM1, CLOCK, PER2, CRY2, Results:  The prevalence of fatigue was 46.3%. Multivariable analysis taking the fatigue score as the dependent vari- able showed that a higher number of cycles and a lower hemoglobin level were significantly associated with higher odds of exhibiting fatigue. Moreover, having at least one C allele for DRD2 SNP (vs. TT) was significantly associated with a 4.09 higher odds of expressing fatigue compared to TT patients. Finally, patients with at least one C allele for CLOCK SNP tended to display higher fatigue levels than TT patients. Conclusions:  Our study showed that anemic breast cancer patients with a high number of chemotherapy cycles and those carrying at least one C allele for DRD2 and CLOCK SNPs are at greater risk of exhibiting fatigue. Since no previous research has reported such genetic results, future studies are necessary to confirm our findings. Keywords:  Breast cancer, Chemotherapy, CLOCK, DRD2, Fatigue, Pharmacogenetics Background According to the 2020 global cancer burden, female breast cancer ranked among the most commonly diag- nosed cancer [1]. In this context, chemotherapy and*Correspondence: aline.hajj@usj.edu.lb radiotherapy remain the mainstay of cancer treatment.† Aline Hajj and Rami Chamoun have contributed equally to this work and Thus, every year more than 2.3 million women encoun-share first authorship2 Laboratoire de Pharmacologie, Pharmacie Clinique et Contrôle de ter numerous side effects with devastating consequencesQualité des Médicaments, Faculty ofPharmacy, Saint-Joseph University on their health [1, 2]. Cancer-related fatigue (CRF) is oneofBeirut, Beirut, Lebanon of the most common and distressing complaints reportedFull list of author information is available at the end of the article © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory ...