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Single fraction ablative preoperative radiation treatment for early-stage breast cancer: The CRYSTAL study – a phase I/II clinical trial protocol

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Breast-conserving surgery (BCS) and whole breast radiation therapy (WBRT) are the standard of care for early-stage breast cancer (BC). Based on the observation that most local recurrences occurred near the tumor bed, accelerated partial breast irradiation (APBI), consisting of a higher dose per fraction to the tumor bed over a reduced treatment time, has been gaining ground as an attractive alternative in selected patients with low-risk BC.
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Single fraction ablative preoperative radiation treatment for early-stage breast cancer: The CRYSTAL study – a phase I/II clinical trial protocol

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