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SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

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To improve current treatment strategies for patients with aggressive colorectal cancer (CRC), the molecular understanding of subgroups of CRC with poor prognosis is of vast importance. SOX2 positive tumors have been associated with a poor patient outcome, but the functional role of SOX2 in CRC patient prognosis is still unclear.
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SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

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