Two childrenwith di¡ering outcomes after treatment for pulmonary tuberculosis diagnosed after allogeneic hematopoietic stemcell transplantation

For recipients of allogeneic hematopoietic stem cell transplantation(HSCT), Mycobacterium tuberculosis may act asa signi¢cant opportunistic pathogen in the early posttransplantationperiod, especially in areas where tuberculosis(TB) is endemic.Incidence and risk factors for mycobacterial infectiondiagnosed in the post-HSCT period have been reviewedpreviously in large cohorts of patients (1^6), with factorssuch as matched unrelated and mismatched transplantations,treatment with total body irradiation, and graftversus-host disease (GVHD) having a signi¢cant impactonTB incidence. However, studies of TB diagnosed solelyin the pediatric HSCT population are scarce, and little isknown of prognostic factors after initiation of anti-TB medication.Most importantly, the severe immunosuppressionthat characterizes the post-HSCTperiod may have a...
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Two childrenwith di¡ering outcomes after treatment for pulmonary tuberculosis diagnosed after allogeneic hematopoietic stemcell transplantation