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Báo cáo khoa học: A selenium-containing single-chain abzyme with potent antioxidant activity

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Reactive oxygen species (ROS) are products of normalmetabolic activities and are thought to be the cause of manydiseases. A selenium-containing single-chain abzyme 2F3(Se-2F3-scFv) that imitates glutathione peroxidase has beenproduced which has the capacity to remove ROS. Toevaluate the antioxidant ability of Se-2F3-scFv, we con-structeda ferrous sulfate/ascorbate (Vc/Fe2+)-inducedmito-chondrial damage model system and investigated thecapacity of Se-2F3-scFv to protect mitochondria from oxi-dative damage. Se-2F3-scFv markedly decreased mito-chondrial swelling, inhibited lipid peroxidation, andmaintained the activity of cytochromecoxidase, in com-parison with Ebselen, a well-studied glutathione peroxidasemimic, indicating that Se-2F3-scFvhas potential for treatingdiseases mediated by ROS....
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Báo cáo khoa học: A selenium-containing single-chain abzyme with potent antioxidant activity

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