Danh mục

Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1

Số trang: 10      Loại file: pdf      Dung lượng: 379.18 KB      Lượt xem: 6      Lượt tải: 0    
Xem trước 2 trang đầu tiên của tài liệu này:

Thông tin tài liệu:

We have identifiedDNA sequences required for the expres-sion of thepresenilin 1(PS1) gene. A promoter region hasbeen mapped in SK-N-SH cells and includes sequences be-tween)118and+178flankingthemajor initiationsite (+1).ThePS1gene is also efficiently transcribed in the SH-SY5Ysubclone of SK-N-SH cells. However the promoter appearstobeutilized inalternativeways inbothcell types. Sequencesboth upstream as well as downstream from the initiationsite mapped in SK-N-SH cells were shown by 5¢-and3¢-deletion analysis to play a crucial role in both cell lines....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1

Tài liệu được xem nhiều:

Tài liệu liên quan: