Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples
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Previous studies have suggested that microRNAs (miRNAs) may playimportant roles in tumorigenesis, but little is known about the functions ofmost miRNAs in cancer development. In the present study, we set up acell-based screen using a luciferase reporter plasmid carrying the whole4.7 kb 3¢-UTR of estrogen receptor a(ERa) mRNA cotransfected witha synthetic miRNA expression library to identify potential ERa-targetingmiRNAs.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples
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Scientific reports scientific research biochemistry cancer cell estrogen receptor medical analysisTài liệu liên quan:
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